Description
Product Characteristics:
Aliases: Intraflagellar transport protein 121 homolog antibody, KIAA1336 antibody, MGC33196 antibody, Naofen antibody, WD repeat domain 35 antibody, WD repeat-containing protein 35 antibody, WDR35 antibody, WDR35_HUMAN antibody
Target Information: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]